Your regular sewing machine and serger works well. The best needle to use is a sharp/new standard needle no.9-11. Best thread would be a polyester or cotton/polyester thread. If your material stretches you want to use a stretch/knit needle. For topstitching you will need a stronger needle such a no.16 as your layers will be quite thick. Choose a longer stitch length because shorter stitch lengths may weaken the fabric. Test the best stitch on a double layer of test material.
Set your tension to a weaker setting so the thread won’t pull too much which may create holes. To pin the material use binder clips or special sewing clips, they work better and won’t create those tiny holes. Synthetic suede may pucker when sewing so you want to hold it taut. Don’t stretch the material. If this method won’t work you could try to tape a piece of tape under the sewing machine foot, often times the slippery surface of tape helps letting the fabric glide better. Other options are to hand baste or use invisible or basting tape to hold the fabric pieces together. A Teflon, roller-ball foot or walking foot might be your last and best options. Avoid back stitching when you start or finish sewing your project because it will help to prevent holes. Best is to tie the thread ends together.
Faux suede is perfect for tote bag:
Since synthetic suede is bulkier than other fabric, you might be better off to first serge/zigzag stitch the raw edges, then sew the inner seam by pinning each one to either side of the fabric and top stitch.
Caring for your finished synthetic suede garment:
Wash your finished project in cold or warm water with little detergent and softener. Dry on low without dryer sheets and steam press if wrinkles occur, with a damp pressing cloth. On garments with interfacing, ovoid the dryer.
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